You can use 1/8 esc, but there is limited space for sc10 4x4, RX8 or Mamba pro those smaller size 1/8 esc will fit, but something like mamba monster or hobbywing 150A may not fit well.
For motor, again, with limited space, SC10 4x4 won't take 40or 42mm 1/8 motor, but 36 mm 540 or 550, I guess 65mm length max. The reason why most people use 4000kv is for race with 2s, if you set your SC10 4x4 to fit 3s battery, (straight pack battery fitment) you can run some 3000kv range motor too. 
For running 2s, hobbywing 120a esc is good and small (can run 3s too) but you may need bec if you run high power servo, I hv no experience with rx8 on 2s, I guess it is ok, if you like tekin, you can choose RS pro instead of rx8, with size advantage.
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