My though is:
-2 stroke nitro can reach very high rpm, praticel rpm is now up to 410,000rpm. Gasoline property can't reach that high rpm, detonation is very easy.
-fuel map control by microchip, no adjustment can be made. This is not flexible for race
Nitro 21 engine (3.5 cc.) 2-strokes usually produce 1+ HP (>700 watt), real car gasoline engine 4 strokes (~2000cc) produce ~150, no doubt nitro 2 strokes produce more HP but life and pollution is also worse.